Cellular Senescence Detection Kit - SPiDER-ßGal

SKU: SG03-10

Availability: In stock

£439.00
Dojindo
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DNA damages of the normal cells are caused by repeated cell division and oxidative stress. Cellular Senescence, a state of irreversible growth arrest, can be triggered in order to prevent DNA-damaged cells from growing. Senescence-associated β-galactosidase (SA-β-gal), which is overexpressed in senescent cells, has been widely used as a marker of cellular senescence. Although X-gal is a well known reagent to detect SA-β-gal, these are following disadvantages: 1) requirement of fixed cells due to the poor cell-permeability, 2) low quantitative capability because of the difficulty of the determination of visual difference between stained cells and not stained cells, 3) requirement of a long time of staining.

Cellular Senescence Detection Kit - SPiDER-βGal allows to detect SA-β-gal with high sensitivity and ease of use. SPiDER-βGal is a new reagent to detect β-galactosidase which possesses a high cell-permeability and a high retentivity inside cells. SA-β-gal are detected specifically not only in living cells but also fixed cells by using a reagent (Bafilomycin A1) to inhibit endogenous β-galactosidase activity. Therefore, SPiDER-βGal can be applied to quantitative analysis by flow cytometry.
Additional Information
Additional Information
Product Code SG03-10
Pack Size 10 Assays
Grade N/A
Cas # [not available]
Storage Conditions -
Sterile N/A
Manufacturer Dojindo
Shipping Conditions N/A
HS Code N/A
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Datasheets
Datasheets
Technical Poster
Technical Manual


Please contact us for further product information.