Oligo Synthesis

Our Experience

For over 15 years, Bio Basic has been synthesizing oligonucleotides for a variety of research applications. Our facilities are especially designed for large volume custom production, incorporating automation to ensure consistent production.

Purification methods include Desalted Purification, High Affinity Purification (HAP – our patented, novel purification method for custom oligos), PAGE, HPLC and HPLC-CE Purification.

Bio Basic also specializes in modified oligonucleotides with a diverse range of modifications available, including Linkers, Spacers, Quenchers, Fluorophores, Modified Bases, Phosphorylation, Probes and many more.

Our oligos are not only of the highest standard, but also the most affordable in the industry, especially for high purity and modifed oligos. This is because we manufacture the majority of our reagents and tools in-house.

To request a quotation or for placing orders, please download our order form (preferred) and email it to our oligo synthesis department at synthesis@biobasic.com. Alternatively, you can email us your sequences directly (including purification type, yield, modifications etc.). Our department will get back to you within 24 hours (on a business day; EST).

Our Pricing and Yield Advantage

Whenever you look for oligonucleotides, you often notice their pricing structure is based on a “scale” or “starting scale” in “nmol” quantity. This can be quite misleading as this actually refers to the quantity ofstarting material” required to synthesize the oligo and gives you no idea about the final yield of oligo you will be receiving.

(This is like going to a bakery where they ask you to pay for your cake based on the quantity of flower, sugar, etc. they will use, and not the final size of the cake).

In addition, based on the oligo facility and methodology(s) used there, the final yield can vary based on the starting material, with some facilities synthesizing higher yields, while others synthesize lower yields, or even mixed yields. In many cases, the final yields are usually not standardized and therefore inconsistent.

We at Bio Basic have modified our oligo synthesis process to allow a simpler and more consistent approach to this pricing structure and final yield deliverable. Because of this we guarantee the total yield of each oligonucleotide as a FIXED final yield in OD (Optical Density) units.

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