Leptin, human

£971.00 exc. VAT

5mg

SKU: RC412-17.SIZE.5mg Category:

Leptin, human: Human Leptin plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. It is one of the most important adipose derived hormones. The Ob (Lep) gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans. The protein is manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. Leptin acts on receptors in the hypothalamus of the brain where it inhibits appetite by (1) counteracting the effects of neuropeptide Y (a potent feeding stimulant secreted by cells in the gut and in the hypothalamus); (2) counteracting the effects of anandamide (another potent feeding stimulant that binds to the same receptors as THC), and (3) promoting the synthesis of α-MSH, an appetite suppressant. This appetite inhibition is long-term, in contrast to the rapid inhibition of eating by cholecystokinin (CCK) and the slower suppression of hunger between meals mediated by PYY3-36. The absence of leptin (or its receptor) leads to uncontrolled food intake and resulting obesity. UnitProt ID: P41159

CAS
Grade
HS Code

2937.19.0000

Manufacturer

Bio Basic

Pack Size

5mg

Shipping Conditions

ICE

Sterile

yes

Storage Conditions

(-15 to -20)C

UNSPSC Category

Other Proteins

UNSPSC Code

12352202

DG
Hazard Class
Hazard UN
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