MANF, human: MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Mature human MANF is 99 %, 98 % and 96 % a.a. identical to mature rat, mouse and bovine MANF respectively. UnitProt ID: P55145
£120.00 exc. VAT
5ug
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| Grade | |
| HS Code | 2937.19.0000 |
| Manufacturer | Bio Basic |
| Pack Size | 5ug |
| Shipping Conditions | ICE |
| Sterile | yes |
| Storage Conditions | (-15 to -20)C |
| UNSPSC Category | Other Proteins |
| UNSPSC Code | 12352202 |
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