NAP-2, CXCL7, human: Neutrophil Activating Peptide 2 (NAP-2) is proteolytically processed carboxyl-terminal fragments of platelet basic protein (PBP) which is found in the alpha-granules of human platelets. NAP-2 is a member of the CXC chemokines. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR-2 and to chemoattract and activate neutrophils. Although CTAP-III, β-TG and PBP represent amino-terminal extended variants of NAP-2 and possess the same CXC chemokine domains, these proteins do not exhibit NAP-2 activity. Recently, it has been shown that the additional amino-terminal residues of CTAP-III masks the critical ELR receptor binding domain that is exposed on NAP-2 and may account for lack of NAP-2 activity. UnitProt ID: P02775
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NAP-2, CXCL7, human
£227.00 exc. VAT
10ug
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Grade | |
HS Code | 2937.19.0000 |
Manufacturer | Bio Basic |
Pack Size | 10ug |
Shipping Conditions | ICE |
Sterile | yes |
Storage Conditions | (-15 to -20)C |
UNSPSC Category | Other Cytokines and Chemokines |
UNSPSC Code | 41116127 |
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Hazard Class | |
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