Polymyxin B sulfate: Polymyxin B sulfate (PMB) is a strongly cationic cyclic polypeptide antibiotic isolated from fermentation of Bacillus polymyxa. PMB is a variable mixture of B1 and B2 (predominantly B1). Polymyxins combine with cell membranes and disrupt normal permeability to small molecules. Polymyxin B and the other polymyxin antibiotics act primarily by binding membrane phospholipids and disrupting the cytoplasmic membrane, inducing pore formation in bacterial walls (large enough to permit nucleotide leakage). Polymyxin B binds to the lipid-A portion of the lipopolysaccharide in the cell membrane of Gram-negative bacteria. The interaction involves ionic forces between amino groups in Polymyxin B and phosphate and carboxyl groups in the lipid A-Kdo region, with hydrophobic interactions between the respective acyl groups. Data suggest a stoichiometric binding of one LPS monomer to one polymyxin B molecule. “Polymyxin B has a bactericidal action on most Gram-negative bacilli (E. coli, e.g.) except proteus spp. … not active against Neisseria species, … most fungi and Gram-positive bacteria.” Activity is inhibited by iron (II), Co (II), Mn (II) and magnesium ions. Polymyxin B may be incompatible with other microbial agents, including amphotericin, cephalothin sodium, cephasolin sodium, chloramphenicol sodium succinate and tetracycline hydrochloride; it is also incompatible with heparin sodium and prednisolone sodium phosphate
Polymyxin B sulfate
£320.00 exc. VAT
25MU
CAS | [1405-20-5] |
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Grade | USP |
HS Code | 2941.90.0010 |
Manufacturer | Bio Basic |
Pack Size | 25MU |
Shipping Conditions | ICE |
Sterile | |
Storage Conditions | 2 to 8C |
UNSPSC Category | Antibiotics and Antimycotics |
UNSPSC Code | 51101500 |
DG | |
Hazard Class | |
Hazard UN |