SHH, murine (mouse)

SHH, murine (mouse): Sonic hedgehog is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and indian hedgehog (IHH). As the hh homologues, SHH has been found to have the most critical roles in development. It acts as a morphogen involved in patterning many systems, including the limb and midline structures in the brain, spinal cord, the thalamus by the zona limitans intrathalamica and the teeth. There SHH undergoes auto-processing to generate a 20 kDa (residues 24 – 197) N-terminal signaling domain (SHH-N) and a 25 kDa (residues 198 – 462) C-terminal domain with no known signaling role. UnitProt ID: Q62226