TNF alpha Variant, Tumor Necrosis Factor-alpha Variant, human

£114.00 exc. VAT

10ug

SKU: RC214-12V.SIZE.10ug Category:

TNF alpha Variant, Tumor Necrosis Factor-alpha Variant, human: The clinical use of the potent antitumor activity of TNF-αhas been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-αmutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-α, which binds to the murine TNF-R55 but not to the murine TNF-R75, exhibits retained antitumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors. Based on these results, many TNF-αmutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo. UnitProt ID: P01375

CAS
Grade
HS Code

2937.19.0000

Manufacturer

Bio Basic

Pack Size

10ug

Shipping Conditions

ICE

Sterile

yes

Storage Conditions

(-15 to -20)C

UNSPSC Category

Other Cytokines and Chemokines

UNSPSC Code

41116127

DG
Hazard Class
Hazard UN
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