TNF alpha Variant, Tumor Necrosis Factor-alpha Variant, human: The clinical use of the potent antitumor activity of TNF-αhas been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-αmutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-α, which binds to the murine TNF-R55 but not to the murine TNF-R75, exhibits retained antitumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors. Based on these results, many TNF-αmutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo. UnitProt ID: P01375
TNF alpha Variant, Tumor Necrosis Factor-alpha Variant, human
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10ug
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Grade | |
HS Code | 2937.19.0000 |
Manufacturer | Bio Basic |
Pack Size | 10ug |
Shipping Conditions | ICE |
Sterile | yes |
Storage Conditions | (-15 to -20)C |
UNSPSC Category | Other Cytokines and Chemokines |
UNSPSC Code | 41116127 |
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