BD-4, beta-Defensin 4, human: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. In addition to its direct antimicrobial activities, BD-4 is chemoattractant towards human blood monocytes. UnitProt ID: Q8WTQ1
BD-4, beta-Defensin 4, human
£114.00 exc. VAT
5ug
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Grade | |
HS Code | 2937.19.0000 |
Manufacturer | Bio Basic |
Pack Size | 5ug |
Shipping Conditions | ICE |
Sterile | yes |
Storage Conditions | (-15 to -20)C |
UNSPSC Category | Other Enzymes |
UNSPSC Code | 12352202 |
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