FGF-21, murine (mouse): Fibroblast growth factor-21 (FGF-21) belongs to the large FGF family and it is specifically induced by HMGCS2 activity. In mice, brown adipose tissue becomes a source of systemic FGF21 after cold exposure. FGF-21 stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression) and the activity depends on the presence of KLB. FGF-21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors. Recombinant murine FGF-21 contains 182 amino acids residues and show limited binding to heparin. In addition, Murine FGF-21 respectively shows 81 % and 92 % a.a. identity to human and rat FGF-21, and it show activity on human and rat cells. UnitProt ID: Q9JJN1

FGF-21, murine (mouse)
£120.00 exc. VAT
5ug
CAS | |
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Grade | |
HS Code | 2937.19.0000 |
Manufacturer | Bio Basic |
Pack Size | 5ug |
Shipping Conditions | ICE |
Sterile | yes |
Storage Conditions | (-15 to -20)C |
UNSPSC Category | Other Cytokines and Chemokines |
UNSPSC Code | 41116127 |
DG | |
Hazard Class | |
Hazard UN |