IL-1RA, Interleukin-1RA, rat: IL-1RA was initially called the IL-1 inhibitor which is encoded by the IL1RN gene and it is a member of the interleukin 1 cytokine family. IL-1RA is secreted by various types of cells including immune cells, epithelial cells, and adipocytes. IL-RA has functions of inhibiting the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the co-receptor IL1RAP for signaling. IL-1RA is also used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. The rat IL-1RA is a single non-glycosylated polypeptide chain containing 152 amino acids and it has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. Rat IL-1RA shares 89 % and 73 % a.a. sequence homology with murine and human IL-1RA. UnitProt ID: P25086
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IL-1RA, Interleukin-1RA, rat
£382.00 exc. VAT
100ug
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Grade | |
HS Code | 2937.19.0000 |
Manufacturer | Bio Basic |
Pack Size | 100ug |
Shipping Conditions | ICE |
Sterile | yes |
Storage Conditions | (-15 to -20)C |
UNSPSC Category | Other Cytokines and Chemokines |
UNSPSC Code | 41116127 |
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Hazard Class | |
Hazard UN |